Fluid recommendation for older adults

For citation : Kuklin VN. Age-related changes in physiology of blood circulation, breath and appropriate anaesthetic considerations in patients older than 60 years. Annals of Critical Care. Read in PDF.
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Evidence-based treatment of neurogenic orthostatic hypotension and related symptoms

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Evidence-based treatment of neurogenic orthostatic hypotension and related symptoms

Neurogenic orthostatic hypotension, postprandial hypotension and exercise-induced hypotension are common features of cardiovascular autonomic failure. Here, we provide a systematic review of the literature on therapeutic options for neurogenic orthostatic hypotension and related symptoms with evidence-based recommendations according to the Grading of Recommendations Assessment, Development and Evaluation GRADE. Based on quality of evidence and safety issues, midodrine and droxidopa reach a strong recommendation level for pharmacological treatment of neurogenic orthostatic hypotension. In selected cases, a range of alternative agents can be considered fludrocortisone, pyridostigmine, yohimbine, atomoxetine, fluoxetine, ergot alkaloids, ephedrine, phenylpropanolamine, octreotide, indomethacin, ibuprofen, caffeine, methylphenidate and desmopressin , though recommendation strength is weak and quality of evidence is low atomoxetine, octreotide or very low fludrocortisone, pyridostigmine, yohimbine, fluoxetine, ergot alkaloids, ephedrine, phenylpropanolamine, indomethacin, ibuprofen, caffeine, methylphenidate and desmopressin. In case of severe postprandial hypotension, acarbose and octreotide are recommended strong recommendation, moderate level of evidence.
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Технологические достижения в управлении уровнем глюкозы у пожилых людей

Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in older adults. Each of these disorders has varied epidemiology, clinical symptomatology, laboratory and neuroimaging features, neuropathology, and management. Thus, it is important that clinicians be able to differentiate and diagnose these conditions accurately. For each condition, we provide a brief overview of the epidemiology, defining clinical symptoms and diagnostic criteria, relevant imaging and laboratory features, genetics, pathology, treatments, and differential diagnosis.
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